Schaffer Collaterals

Tuesday, February 15, 2011

Schaffer collaterals are axon branches which are given off by Ammon's horn CA3 pyramidal neurons in the hippocampus. Schaffer collaterals project to area CA1 of the hippocampus and are an integral part of memory formation and the emotional network of the Papez circuit, and of the hippocampal trisynaptic loop. In the early stage of long term potentiation Schaffer collaterals release glutamate that binds to AMPA receptors of CA1-dendrites. The collaterals ared named after the Hungarian anatomist-neurologist Karoly Schaffer.