Denervation Atrophy

Tuesday, April 3, 2012

Denervation atrophy, also known as neurogenic atrophy, is the reduction in the diameter of muscle fibers and a decrease in the amount of contractile proteins they contain, due to the distruction of innervating motor neurons and/or their neuromuscular junctions, which causes discontinuation of the muscle nerve supply. Denervation atrophy is always accompanied by paralysis and is caused by several sindromes. A muscle can also atrophy with its nerve supply intact if the muscle is not used for a long period of time, as when a broken arm or leg is immobilized in a cast. This condition is known as disuse atrophy.