Desipramine hydrochloride is a drug indicated for the relief of mental depression. Clinically, onset of action is rapid, usually within three to five days and is manifest as a lifting of depressed mood and a restoration of psychomotor activity. Sold under the brand name of Pertofrane, is a metabolite of imipramine hydrochloride. It is a white crystalline substance, with a molecular weight of 302.8. Desipramine hydrochloride is a dibenzazepine derivative.
The drug is metabolized in the liver. About 70% is excreted in the urine.
The use of desipramine hydrochloride, concomitantly or within two weeks of the administration of MAO inhibitors is contraindicated. Hyperpyretic crisis or severe convulsive seizure may occur in patients receiving such combination.