Dipyridamole

Tuesday, March 11, 2014

Dipyridamole is classified as coronary vasodilator and is used in the long-term treatment of chronic angina pectoris. Prolonged may reduce or eliminate angina episodes and improve exercise tolerance. Sold under the brand name of Persantine, this drug increases coronary blood flow by a selective dilation of the coronary arteries. Dipyridamole increases coronary sinus oxygen saturation without signifantly altering myocardial oxygen consumption.

Dipyridamole is a homogeneous yellow crystalline powder, odorless, with a bitter taste. It is soluble in dilute acids, methanol, and chloroform. Its basic structure is a double ring of two condensed pyrimidine rings. Chemically, it is designated as 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d) pyrimidine.