Methyclothiazide is a potent diuretic antihypertensive agent. Sold under the brand name of Enduron, it is used in the treatment and control of edema associated with congestive heart failure, the nephrotic syndrome, hepatic cirrhosis, pre-menstrual tension, and steroid therapy. Methyclothiazide is a member of the benzothiadiazine (thiazide) family of drugs. It is an analogue of hydrochlorothiazide.
This drug should be used with caution in pregnant women and nursing mothers since thiazides cross the placental barrier and appear in cord blood and in breast milk. Side effects that may accompany methyclothiazide therapy include anorexia, nausea, vomiting, diarrhea, headache, dizziness, paresthesia, weakness, and skin rash. Thiazides have been reported, on rare occasions, to have elevated serum calcium to hypercalcemic levels. The serum calcium levels have returned to normal when the medication have been stopped.