Pargyline Hydrochloride

Friday, June 20, 2014

Pargyline hydrochloride is a monoamine oxidase inhibitor used in combination with methyclothiazide to treat arterial hypertension. A monoamine oxidase is an enzyme found in the cells of most body tissues; it catalyzes the oxidation of norepinephrine, causing the blood vessels to constrict. Thus, as a monoamine oxidase inhibitor, pargyline blocks the action of this enzyme, making the arterial walls to relax and expand.

Pargyline therapy is contraindicated in patients with pheochromocytoma, paranoid schizophrenia, hyperthyroidism, and advanced renal failure.