Friday, April 24, 2009


Azlocillin is a semisynthetic, broad-spectrum, bactericidal antibiotic which belongs to the group of penicillins. Azlocillin is an acylampicillin which binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the cross-linking of peptidoglycans, which are critical components of the bacterial cell wall. This prevents proper bacterial cell wall synthesis, thereby results in the weakening of the bacterial cell wall and eventually leading to cell lysis.

Azlocillin is prescribed for the treatment of lower respiratory tract, urinary tract, skin, bone, and joint infections, and bacterial septicemia caused by susceptible strains of microorganisms, mainly Pseudomonas aeruginosa.