Although the Tupungato is geologically considered as an extinct volcano of the Pleistocene period, the holocene Tupungatito volcano, located immediately in the Southwest direction and with which it is usually confused, is active with 18 eruptions registered from 1829. The lasts of these were light emissions of ash in 1980 and 1986.
On August 2, 1947, the airliner Star Dust, an Avro Lancastrian carrying 11 passengers over the Andes range, crashed into a steep glacier high on Tupungato. The plane was quickly buried in the resulting avalanche and heavy snowfall that was taking place at the time. The plane lay undetected deep beneath the snow and glacial ice for over 50 years, before its remnants finally re-emerged at the glacier terminus in 2000. Shortly thereafter, a team discovered the scattered debris and wreckage, collecting some of the evidence for investigation.