Descemet's membrane, or posterior limiting membrane, is the basement membrane located between the corneal stroma, and the endothelial layer of the cornea. It is a thin acellular layer which serves as the modified basement membrane of the corneal endothelium, from which the cells are derived. This layer is composed mainly of collagen type IV fibrils, less rigid than collagen type I fibrils, and is around 5-10 µm thick, depending on the subject's age. Damage to the Descemet's membrane may require a corneal transplant as the endothelial cells depend on it for support and cannot re-grow after injury without it.
The Descemet's membrane is the specialized basement membrane of the endothelial cells positioned between the stroma and the endothelial cell layer. Any condition that causes inflammation of the cornea or the anterior chamber can cause Descemet membrane folds.