Myocardial lipidosis is the accumulation of fat droplets in myocardial fibers. It is a progressive metamorphosis of the myocardium in which it gets friable and acquired a pale yellowish color. Myocardial lipidosis is not a cause, but the result of heart failure. Being part of a generalized disorder, it progressively deteriorates and weakens the heart muscle. Myocardial lipidosis may be caused by arsenic or phosphorus intoxication and cardial hypertrophy due to hypertension or some kind of cardiomyopathy. Myocardial lipidosis can lead to focal necrosis and fibrosis.