Wednesday, February 8, 2012
Lymph Flow Mechanism
The lymphatic vessels beyond the lymphatic capillaries propel the lymph within them by their own contractions. The smooth muscle in the wall of the lymphatics exerts a pump-like action by inherent rhythmical contractions. Since the lymphatic vessels have valves similar to those in veins, these contractions produce a one-way flow toward the points at which the lymphatics enter the circulatory system. The lymphatic vessel smooth muscle is responsive to stretch, so when there is no accumulation of interstitial fluid, and therefore no entry of lymph into the lymphatics, the smooth muscle is inactive. As lymph formation increases, however, say as a result of increased fluid filtration out of blood vessel capillaries, the increased fluid entering the lymphatics stretches the walls and triggers rhythmical contractions of the smooth muscle. This constitutes a negative feedback mechanism for adjusting the rate of lymph flow to the rate of lymph formation and thereby preventing edema. In addition, the smooth muscle of the lymphatic vessels is innervated by sympathetic neurons, and excitation of these neurons in various physiological states such as exercise may contribute to increased lymph flow. Lymph flow is also enhanced by forces external to the lymphatic vessels. These include the same external forces we described for veins—the skeletal muscle pump and respiratory pump.