The body tissue repair begins right after the acute inflammatory reaction as a result of tissue damage. It is the replacement of dead cells by new viable ones. These new cells may originate from the damaged parenchyma (an organ cellular structure) or from connective tissue in the damaged area. However, parenchymatous regeneration is very slow, since the cells that perform the organ main function are stable and it takes a long time for them to multiply, as is the case with hepatocytes, the cells that constitute the liver; when this organ is damaged by either viral infection or alcohol, it is the organ connective tissue cells that does the repair as they multiply much faster.
Unfortunately, when the liver is repeatedly wounded by a chronic disease or alcoholism, the liver parenchymatous cells (hepatocytes) do not have time to undertake the repair and are overtaken by connective tissue cells; and overtime, the organ become fibrous and regid, rendering the organ unable to perform its functions. Thus, fibrosis is due to connective tissue repair.